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bharathi
India-Tamilnadu-Chennai
Bioinformatics job
Seeking a challenging career in your esteemed organization, where my knowledge can be shared and enriched. I would like to have an opportunity to contribute effectively for the growth of the organization I work for and will in turn contribute to my personal growth.
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xposure:
• Languages : C++, HTML, PERL.
• Operating Systems : Windows XP, MS-DOS, Windows 9x/2000/NT, UNIX.
• Database : MS-Access and SQL Server, Oracle.
Technical Training:
Summer training in certificate course on drug and development- Anna University,
MIT Campus
Area of Interest:
INSILICO DRUG DISCOVERY & SYSTEMS BIOLOGY ANALYSIS.
Project:
MATHEMATICAL SIMULATION OF THE CASPASE ACTIVATION INVOLVED IN APOPTOSIS SUPPORTED BY THE PHARMACOPHORE CONSTRUCTION FOR BERBERINE.
Software used:
GEPASI, CELL DESIGNER, COPASI.
Place:
AU-KBC RESERCH CENTRE, Anna University, MIT Campus, Chennai.
Project Description:
My project work was consists of two parts
Mathematical modelling of caspase pathway.
Apoptosis is an important physiological process crucially involved in development and homeostasis of multicellular organisms. I have modeled the caspase, which is the aspartate-directed cysteine proteases cleaves the protein plays an important role in the apoptosis..
Simulation of caspase pathway.
Simulation of this pathway shows the degradation of the caspase protein and its inhibited by IAP, which is the inhibitor of apoptosis. In my project work i have studied caspase protein and its inhibition by IAP.
The pharmacophore conastrcution for berberine with caspase.
Berberine, an isoquinoline plant alkaloid, is known to generate a wide variety of biochemical and pharmacological effects. Finally I have studied the pharmacophore construction of berberine with the caspase.
Bio-Informatics Literacy
• Knowledge of Bio-Informatics tools like Clustal W, Multalign, Interpro, Mast Meme,
Clustal X, n-n predict, Prosite, e-motif, P-fam, BLAST, Phylodendron, etc.
• Knowledge of Homology based protein modelling using the software MODELLER,
HOMOLOGY.
• Docking analysis of peptide-DNA complexes and Peptide-peptide complexes using
Hex , Argus lab and Autodock Softwares.
• Mathematical modellling and simulation of metabolic pathway using the tools
Gepasi, Copasi, Cell designer,
Co - / Extra - Curricular:
Participated & won prizes at national level seminars in Poster Presentation
Personal Details:
Father’s Name Balachandar.V
Date of Birth 27 January 1984
Sex Female
-Mailing Address 3 A, South Pragaram Street,
Kaladipet, Thiruvotrriyur,
Chennai-600 019.
Tamil Nadu
Mother Tongue Tamil
Languages
• To Read English, Tamil
• To Write English, Tamil
• To Speak English, Tamil¬
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