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William
Canada-Ontario
Research associate
Clinical Research Associate
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ensive knowledge of Microsoft office package (Microsoft Word, Excel, PowerPoint, Access, Outlook express)
7+ years of computer management experience
SPECILIZED TRAINING:
Trainee in Clinical Research Associate program 2007-present
The Michener Institute, Toronto, ON, Canada
Courses:
Communication and Technology
Ethical Issues in Clinical Research
Principles of Clinical Research I
Principles of Clinical Research II
EMPLOYMENT EXPERIENCE:
Research Associate (Cell & Mol. Biology)/System Manager 2006 – Present
Center for Molecular Design and Preformulations
Division of Cell. & Mol. Biology, Toronto General Research Institute, Toronto, ON.
Conduct therapeutic efficient new drug design projects
System manager of super computing system
Research Scientist 2005 - 2006
Lorus Therapeutics Inc. Toronto, ON.
Preclinical research on anti-cancer drug candidates using animal models
Optimized anti-cancer drug candidates, including QSAR model building, combinatorial library design, and virtual screening
Performed new drug design by the way of computer modeling
Postdoctoral Fellow / Scientific Consultant / System Manager 2001 - 2005
Faculty of Pharmacy (MDIT Centre), University of Toronto, Toronto, ON.
Protein – protein & protein – inhibitor interactions:
Built interferon – interferon receptor interaction models
Investigated nitric oxide synthases active site and model inhibitor binding
Processed in silico database screen against human proteases
Built homology model of GPCR
Structure based drug design:
Designed synthetic HIV peptide mimics for use in HIV vaccine research
Built Insulin – insulin receptor interaction model. Designed small molecule mimics of insulin
Performed computer-aided investigations and structure-based drug design of therapeutically important serine proteases
Conducted orotidine monophosphate decarboxylase modeling, inhibitor design and mechanistic evaluation
Scientific Consultant and System Manager:
Provided scientific consultation and support for collaborative researchers and industrial partner
Maintained super computing system and scientific software
Assistant Professor of Chemistry 1999 - 2001
Nankai University, Tianjin, China
Developed nonlinear QSAR methodologies such as artificial neural network (ANN), coupling with genetic algorithm (GA) and applications in herbicide candidate screening
PhD Candidate in Computational Chemistry 1994 - 1999
Nankai University, Tianjin, China
Designed and programmed the NKCAD (Nankai computer aided molecular design) software package
Designed and programmed a chemical structure displaying plug-in software for ICDD (International Center for Diffraction Data)
EDUCATION:
PhD Computational Chemistry 1999
Nankai University, China
Thesis: Computer aided-molecular design - QSAR model development
B.Sc. Chemistry 1989
Nankai University, China
References and Publications Available Upon Request
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