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REMYA
India-Gujarat-Kandla
project assistant
i had completed M.Sc Bioinformatics.As part of curriculam i had studies Basic C, VNB,ORACLE,LINUX and PERL
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India
Mobile: 09985912172
OBJECTIVES
Intend to build a career with leading corporate of hi-tech environment with committed and dedicated people who will help me explore myself fully and realize my potential.
Willing to work as a key player in a challenging environment.
ACADEMIC CHRONICLE
MSc Bioinformatics
University : Bharathiar University
College : Karpagam Arts and Science, Coimbatore
Aggregate : 73%
Year of Passing : 2007
BSc Mathematics
University : Kerala University
College : T.K Madhava Memorial College Nangiarkulangara
Aggregate : 80%
Year of Passing : 2005
Plus Two
Board : Board of Higher Secondary Examination
School : K.V S.H.S.S
Aggregate : 59%
Year of Passing : 2002
Matriculation
Board : Board of Higher Secondary Examination, Kerala
School : B.B.H.S, Nangiarkulangara
Aggregate : 64.3%
Year of Passing : 2000
Certification Coursers:
Accelrys certified professional in Protein Modelling & Rational Drug designing in Biocampus, GVK Bio.
Description:
Accelrys certified professional in computer aided drug discovery and design expertise on working with Cerius 2, Insight II, Autodock and ISIS softwares.
TECHNICAL QUALIFICATIONS:
Protein Modeling & Rational Drug Designing:
Protein Modeling
• Sequence searching and alignment tools: BLAST, FASTA & CLUSTALW
• Comparative Modeling of Proteins: Homology, Modeler, SeqFold, Profiles 3D, CharmM, Delphi, Binding Site and other Modules of Insight II (MSI) on SGI Octane Workstations.
Computer aided drug designing: Drug Discovery on Insight II, Cerius2 and Catalyst platforms which include:
• Molecular Modeling: Force Fields, Molecular Mechanics and Quantum Mechanics.
• Energy Minimization, Molecular Dynamics, Monte Carlo simulations, Conformational Search.
• Pharmacophore Analysis: Generation, Hypothesis, and Validation for bioactivity.
• Analogue Based Drug Design: 3D-QSAR, Multivariate statistics, and Analog Builder.
• Structure Based Drug Design: Lead generation, Lead Optimization, Docking and Scoring, Affinity, and DeNovo Ligand design.
• Cheminformatics: Combinatorial library, Validation, Similarity, Databases such as PDB and CSD.
WORK STATION AND PLATFORM:
The experimental part of the work is carried out on SGI-02 workstations with IRIX-6.2 version, platform.
PROJECTS:
Major Project
Protein Modeling of Human Cardiotrophin-1 protein at GVK BIO, Hyderabad.
Team size : 1
Duration : 3 month
Platform : Linux
Software : INSIGHT II
Tools : Homology Modeling, MODELLER, Procheck, Prosite, Swissprot, NCBI, PDB.
Features
Design the Two Dimensional and Three Dimensional Strcture of HUMAN CARDITROPHIN-1 using the validations like RIBBON Validation, Table Validation and PROCHECK using the tool MODELLER .
Design the Two Dimensional and Three Dimensional Strcture of HUMAN CARDITROPHIN-1 using the validations like Table Validation and PROCHECK using the tool Homology Modeling.
Identified its function.
Mini Project
1: INSILICO ANALYSIS OF DNA REPAIR PROTEIN IN HOMOSAPIENSE.
Team size : 2
Duration : 1 month
Platform : windows
Software : available online tools
Features
Select the sequences using HPRD.
Identifying the Binding site of DNA Repair Proteins using PSSM.
Identifying the Transmembrane protein of DNA Repair Protein using TMpred.
Identifying the fold of DNA Repair Protein SEQFOLD
2: IN SILICO STUDIES ON NEW TYPE OF METALLOPROTEINASE-1 INHIBITORS.
Team size : 2
Duration : 1 month
Platform : Linux
Software : INSIGHT II, Cerius2, and Catalyst.
For duration of 1 month live project in Biocampus, Gvkbio for the fulfillment of course of “Protein Modeling and Rational Drug Design”.
Description:
New lead identification studies carried out by pharmacophore based search method (Catalyst software) and studied the structure based and analog based drug design strategies for MMP1 inhibitor. Docking method like, Ligand fit and Autodock (Scripps research institute) were also employed. In QSAR studies, a new method employed were the molecules with high dock score were selected from Ligandfit result that showed good orientation and geometry at the receptor active site. The criteria changed for selecting training set molecules, where an order of magnitude of all molecules is considered.
ACHIEVEMENTS
Pursuing the course, Accelry’s certified professional in Protein Modelling & Rational Drug designing in Biocampus, GVK Bio.
Active participation in the organizational activities of all co-curricular activities of the college and class.
Presented a poster in National level seminar ‘motif 2005’ conducted by Bharathiyar University.
Participated in one day national level Bioinformatics workshop on Drug Designing conducted by Schrödinger (USA).
AREA OF INTEREST
RDBMS Concepts
Sequence Alignment
Secondary Structure Prediction
Drug Designing
Protein modeling
Basic C language
PERL
Visual Basic
Oracle
Linux
SQL
IRIX
HOBBIES
Listening to Music, Reading books.
COMPUTER PROFICIENCY
Operating system : MS DOS, WINDOWS 98/2000/XP, IRIX, LINUX.
Language : C, PERL, VB.
Data bases : SQL, ORACLE.
Operating systems :WINDOWS, LINUX
Software Used
Insight II
Cerius2
Catalyst
HEX
Tools used
Tools used for Protein Modeling: - HOMOLOGY, MODELLER SWISS PDB, SWISSPROT, PROSITE, PROCHECH, SEQFOLD, PROFILES 3D, Blast, FASTA, PDB and Clustal W.
Tools used for Insilico Analysis of DNA REPAIR PROTEIN In HOMOSAPIENS:-
HPRD
TMpred:-Used to predicting the transmembrane regions and orientations.
RPfold and Seqfold:-Used to recognize the fold present in the protein.
PSSM:-Used to identify the DNA Binding residues.
ELM:-Used to identify the Motif Regions present in the protein.
Other tools used: NCBI, BLAST, FASTA, CATH & SCOP Databases, Delphi, LUDI, Rasmol, Ramachandran Plot, QSAR,
PERSONAL PROFILE
Name: : Remya .P
Sex : Female
Date of Birth : 21-01-1985
Marital Status : Single
Nationality : Indian
Linguistic Abilities : English, Hindi, Malayalam, Tamil (R/W/S)
Alternate E-Mail id : remyapankaj@rediffmail.com
Permanent Address : Sreepadam
Chingoli.p.o
Alappuzha (Dist)
Kerala (State)
Pin code: 690532
Phone No: 04792485500
Declaration
I, REMYA.P hereby declare that the above said information is true and correct to the best of my knowledge.
SIGNATURE
Date :
Station : (Remya.p)
Basic C,VB,ORACKE,LINUX and PERL
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